Published in the journal Nature Genetics, the international research project analyzed genetic data from over one million individuals across several countries. The findings indicate that people with a genetic predisposition for cannabis use disorder (CUD) are also more likely to carry genetic markers linked to psychiatric conditions such as schizophrenia, bipolar disorder, and attention-deficit/hyperactivity disorder (ADHD).
Rather than suggesting that cannabis causes mental illness directly, the study points to a shared biological vulnerability. “This is not about cannabis triggering these conditions in everyone who uses it,” said Dr. Emma Johnson, one of the lead researchers. “It’s about overlapping genetic risks that may make some individuals more susceptible to both cannabis misuse and mental health challenges.”
The study used a genome-wide association approach, examining hundreds of thousands of small genetic variations across participants. Researchers found that certain genetic profiles linked to CUD also showed significant associations with major psychiatric diagnoses.
This isn’t the first time cannabis has been connected to mental health concerns, but this study offers one of the most comprehensive genetic analyses to date. It helps explain why only a subset of cannabis users develop problematic use or psychiatric symptoms, while others do not.
As cannabis legalization expands across the United States and worldwide, these findings add a new layer of nuance to ongoing public health conversations. Advocates for responsible use say the research underscores the importance of screening and support systems, particularly for those with a personal or family history of mental illness.
“Understanding these genetic correlations is crucial,” said Dr. Johnson. “It’s a step toward more personalized approaches to both mental health treatment and cannabis policy.”
While further research is needed to untangle causation from correlation, the study’s findings serve as a cautionary reminder: cannabis may not affect everyone the same way, and genetics could play a key role in determining those differences.
As public interest in both cannabis and mental health continues to grow, this new study offers valuable insight into how science can help guide safer and more informed decision-making—for individuals, clinicians, and policymakers alike.
Dabbin-Dad Newsroom
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