A new study has revealed that low doses of cannabis, administered over the long term, can reverse brain ageing and enhance cognitive abilities in mice. Conducted by researchers from the University Hospital Bonn, the University of Bonn in Germany, and the Hebrew University of Jerusalem, the study suggests potential anti-ageing treatments for the human brain, a TOI report stated.
Key Findings on THC and Brain Function
The research, published in ‘ACS Pharmacology & Translation Science’, indicates that tetrahydrocannabinol (THC), the active compound in cannabis, plays a significant role in restoring cognitive functions. The study highlights the manipulation of the protein switch mTOR (Mechanistic Target of Rapamycin) as a crucial factor in regulating both metabolism and cognitive performance.
Professor Dr. Andreas Zimmer, Director of the Institute of Molecular Psychiatry at the University Hospital Bonn, explained the importance of mTOR activity in brain ageing. “Anti-ageing strategies based on the reduction of mTOR activity might not only be ineffective but even counterproductive against brain ageing. In our current work, we have now found a strategy to solve this dilemma,” Zimmer stated.
Dual Impact of THC on Brain and Body
The research delved into how THC influences mTOR signalling and the metabolome, encompassing all metabolic properties of a cell. The study found that in the brain, THC increased mTOR activity, which in turn boosted energy production and the formation of synaptic proteins, leading to improved cognition.
In contrast, the researchers observed a reduction in mTOR activity in other parts of the body, such as adipose tissue. This reduction is similar to the effects of a low-calorie diet or intense physical exercise. Dr. Andras Bilkei-Gorzo, a member of the research team, noted, “Our study suggests that a dual effect on mTOR activity and the metabolome could be the basis for an effective anti-ageing and cognition-enhancing drug.”
Implications for Future Research
The findings from this study open up possibilities for developing new anti-ageing treatments for the brain, potentially benefiting cognitive health in humans. Further research is needed to explore how these findings could be applied to human subjects and to develop safe and effective therapies.
H/T: economictimes.indiatimes.com
